Thousands have perished in the deadliest fires in U.S. history, according to rankings compiled by the National Fire Protection Association.
12. Port Chicago explosion -- An estimated 322 sailors and civilians died in this munitions explosion at the Port Chicago Naval Magazine in Port Chicago, Calif., in 1944.
11. Hoboken Docks fire -- This blaze sparked by cotton bales catching fire killed at least 326 people in and around the piers in Hoboken, N.J., in 1900.
10. Monongah Mine disaster -- A methane explosion ignited coal dust in this West Virginia mine in 1907, killing 361 workers.
9. Hinckley fire -- Several small fires merged to create a firestorm that burned up to 250,000 acres in and around Hinckley, Minn., in 1894, killing 418 people.
8. Texas City disaster -- The deadliest industrial accident in U.S. history, 468 people died when a fire on board the SS Grandcamp in Texas City, Texas, detonated approximately 2,300 tons of ammonium nitrate, causing a chain reaction of fires and explosions in 1947.
7. Cocoanut Grove nightclub fire -- The deadliest nightclub fire in U.S. history, the blaze killed 492 people in Boston in 1942.
6. Cloquet fire -- Sparks from the local railroad caused this massive fire in Cloquet, Minn., that burned 250,000 acres and killed 559 people in 1918.
5. Iroquois Theater fire -- The deadliest theater fire in U.S. history killed 602 people after a light shorted and ignited a muslin curtain at the Iroquois Theater in Chicago in 1903.
4. General Slocum steamship fire -- An estimated 1,021 of the 1,342 people on board this steamship died when it caught fire and sank in New York's East River in 1904.
3. Peshtigo fire -- This 1871 firestorm caused the most deaths by fire in U.S. history, killing more than 1,100 people in Peshtigo, Wis.
2. S.S. Sultana steamboat explosion -- This Mississippi River steamboat paddlewheeler exploded and sank near Memphis, Tenn., in 1865, killing 1,547 people.
1. World Trade Center explosion -- More than 2,600 people perished after two planes crashed into New York's World Trade Center on Sept. 11, 2001, causing intense fires that ultimately led to the Twin Towers' collapse.